I agree with NBK and Ryan, especially if you are pursuing mature bucks. Some spots, despite the sign, just should not be hunted.
A friend of mine used to carry dried milk weed pods and while sitting stand, would occasionally release some seeds to watch what they did. Learned a lot about why deer that are, in theory, upwind suddenly scent you and know where you are. Currents of air move all over, and not always as you'd expect.
I've had some areas where I found great sign, set up, and never finished a sit because of wind instability. Thinking maybe it was just my luck the first time, I've returned, to have the same situation, and I've abandoned those locations permanently. I live in an area that is full of hills, coulees and draws. Hunting the wind can be tricky in this kind of terrain.