I take it from your post that your wife is left eye dominant. It makes life so much easier if you can just look at the target and have your arrow go where you're looking, without having to squint or make other accommodations for not having your dominant eye over the arrow. Of course, your arrow won't go where you're looking until you learn how to shoot, but that's true for all of us.
I shoot ambidextrously, not well, but comfortably. The reason I don't shoot left handed as well as right handed is that I'm right eye dominant. But as far as learning to draw the bow to anchor left handed, hold, and shoot, there was about two weeks worth of awkwardness, and then it felt fine. I've been in classes where the instructor recommended a student switch to left handed because of left eye dominance and the student successfully made the transition by the end of the class. It's not the same as writing: we are not pre-programmed to pull the bow one way or the other. It's more like carrying a suitcase: we carry it with one hand until that hand gets tired and then switch to the other hand.
If your wife is truly left eye dominant, I recommend that she switch to a left handed bow. After an initial period of awkwardness, she will enjoy archery more than she did before.