I just ordered a 43 # @ 29" from Dan, one of his famous " Whip " bows, I'm really looking forward to it. With it tuned, and a two blade broadhead, it should be able to take anything in North America. Close encounters of course, five to 30 yd., as long as you keep your cool, and do what's right, 40, 45, is a great poundage, for accuracy. I don't think it is so much the poundage as to " how " you use your equipment.
Of course I'll probably work up to about 48, but for right now 43 #is just fine.
Pastor Carl