In my experiments, I have found that two factors make a ton of difference.
1. As Kenny mentioned, the sight window makes a difference, if it is cut exactly to center versus another bow that has a window cut short of center. If the window is short of center, the bow will require a weaker dynamic spine. In some cases this is quite a bit. I have a recurve that is just a bit short of center and the dynamic spine of a tuned arrow is 13 pounds lighter than the draw weight of the bow.
2. High FOC can have an effect as well. I have a bow that is cut precisely to center, and in making 27% FOC arrows for it, I found that I needed arrows that had a dynamic spine that ended up 8 pounds weaker than the draw weight of the bow. It did not make sense to me at first, but the arrows shoot like laser beams.
I think the spine charts can be a good starting place, but each bow has its own personality and meticulous tuning (in my case bare shaft tuning) will be the best way to arrive at the correct arrow formula. In addition, high FOC will influence the necessary dynamic spine of the finished arrow.