Lots of good info already stated... I have some recent experience to share. I've always followed the Ashby Studies and to me it's hard to refute. Yes, there are success & failure stories on both sides of the aisle, but physics is physics and I think you can set-up your arrows for better bone breaching capabilities. Trajectory is a trade-off depending on how far you really need to shoot. For me out of Treestands or 20 yards and under, the trajectory is not a big deal... Here's a link to a thread I just typed up, and on Page 9 I just updated shot specs & pics! Great advice is to not hit the shoulder bone (at least on entry). But, we're not perfect AND the animal doesn't always cooperate...
http://tradgang.com/noncgi/ultimatebb.php?ubb=get_topic;f=1;t=123089 By the way, this year was my first year to dial-in the heavier arrows with High F.O.C.. I finally pulled the trigger after years of following Ashby's studies AND listening to him speak @Kazoo :-)