remember, when shooting up or down at severe angles, you need to either practice to get used to the difference, or, bend at the waist so your head lines up with the arrow like before and the rest of your draw remains constant. Shooting down is NOT the same as shooting horizontally. Some take to it easily, some, not so easily.
Also, if you don't already know this, remember to change your aiming place on the deer, depending upon how it is facing and upon your height. Many recommend "looking thru" the deer and aiming to put the arrow thru the opposite leg.
ChuckC