If we are talking about Pop-Up commercial blinds then I would say that the size, weight, and packability while not great are not inhibiting factors. I have carried mine far on my shoulder and if a really long haul have strapped it to my packframe.
The biggest reason I do not use mine (Double Bull T-5) more is that it is not as versatile or as effective as a treestand. If treestands were not an option then I would probably use it more.
It does limit your vision and the "peripheral" experience.
I think the best way to use it for public land hunting is to wait till you find a good or required scenario for it. For example a well defined trail in front of a big deadfall or a good area with small trees that a stand just cannot go in. In this situation I consider it “better to have bad tree in a good spot than a good tree in a bad spot” (Wensel paraphrase).
If you are on private ground and the blind can be left up for prolonged periods then that is a completely different situation.
Almost all of my hunting is on public property but I have used blinds on private ground as well with mixed results. In a situation (South Texas) where the blind was left setup for prolonged periods hogs, javalina, and deer paid it no mind. In another situation (Florida) I set one up for several days and the hogs were very wary of it. The next day I setup a treestand in nearly the same spot where the blind was and shot a hog.
Hope this helps.