Are you planning on a High-country hunt? I have done 5 solo, backpack, hunts for mulies. 4 in Colorado and 1 in Utah.
I began by researching units that I could easily draw. Once I narrowed it down to a couple of units, I started looking for areas with a lot of basins. Spots where I could glass multiple basins with out having to travel great distances.
I used google earth to get a feel of topography. I found a website,www.summitpost.org, it's a hiking site that shows trail heads into different mountains. Hikers will often attach photos of the area. I use the photos to look at the vegetation In the area to see if it's suitable for deer. Usually looking for willow.
I also, look for water. For me mostly. I had to pack water in Utah. Vowed never to do that again!
I've never hunted Wyoming but hope this helps.
Seth