In terms of how the arrows fly once they leave the bow, I believe it makes no difference.
Slow motion photography clearly shows the arrow does not start to spin until well after it clears the bow riser, and most times the paradox brings the feathers nearly clear of the riser anyway.
In terms of other things, like twisting off screw in heads, needing to match your single bevel heads to the feather, or feather orientation putting the lower feather right where it impacts your hand on release, those are the things that might matter.
ChuckC