One thing to consider;
It's one thing to hunt with a bow that has enough FPS/KE to give a clean pass-through and humane kill. But all the so-called 'experts' tell you that you need to practice with the same tackle you intend to hunt with.
This is where it gets sticky for me.
I can get off a nice shot with my 55# Sage even in full cold weather gear, but practicing for an hour or more will tear me up. 45# is a compromise between my super-accurate Tamerlane at 35# and my Sage at 55. If you want the higher DW hunting bow, sometimes that means limiting your practice session times and # of shots, or practicing with a lighter bow. I find the 45# to be easy on the body for practice, yet possessing enough KE for a clean kill most of the time.