Three important factors besides bow length and poundage are...
1. How long is your riser from fade out to fade out? (Major factor)
2. How wide do you want your bow to be? (major factor)
3. How much backset (total reflex) does your bow have? (a factor, but not as critical as the other two)
I just started making bows, but I would never use just one lamination as a core. I don't think I will ever use anything over 0.100 either, but in most cases I will stay under 0.08 as a max lam thickness.
If I needed a total core of 250, I would use about 90-100 of synthetics (50 on belly and 40 or 50 on the back) and 150-160 natural materials. Of the 150, I would break it into 50, 50, and 50-60 for the remaining lamination.