Just for the sake of testing a bow while building it, I have no issues shooting left handed at all. But I haven’t spent enough time with it to get proper alignment at full draw. It seems really uncomfortable after shooting RH so long.
After that Avatar movie came out, I played around with flipping my string hand upside down on the string like they do on that film. Besides the fact I couldn’t keep the arrow on the shelf without holding it with a finger, I really liked the feel of the draw with my hand in a thumbs down position. It Reminded me of using a back tension rope release I spent a lot of time with years ago in competition.
I tried this upside down hook on a LH bow shooting RH just recently and it worked fine keeping the arrow on the shelf and it was easier to draw a 55-60 pound bow. That’s where I struggle most shooing left handed, is getting heavier draw weights back smoothly. I never got into a swing draw habit. I use the rotational draw technique.
Accuracy wise… I think with a bit more practice I could easily shoot left handed as well as I can right handed, but I seem to do better with a slight cant and an open stance shooting off hand LH.
Try that Avatar string hook on a lefty shooting right handed some time. It’s kind of fun. Kirk