Buckey, I've had 27 different bows and I have never been concerned. I killed animals with just about every one of them, and they all shot where I looked and with the same exact nock point. I have also shot the same arrows, except for a few exceptions, for the last 19 years with heads from 150 to 225 grains out of bows from 55 to 78#s.
I have also shot chartreuse 3 and 4 fletch forever for more than one reason , but one is that I can see arrow flight really good. I never have had problems running 4 blades through just about everything I've killed unless I hit the off shoulder or off upper leg bone from quartering away. I've also shot pheasants with 2 different bows the same day.(had to kill one for a new Sponsor's bow and the other one was a Mohawk Rob Distefano had made for me) I killed 2 with each bow that day.
All I've ever really done is change head weights a few times to get the flight I wanted. But most every one of those bows where shooting a 175 grain head on a 585 grain arrow.