I always shoot for the heart area. If they load up the arrow will still be in the kill zone lungs or the top of the heart area. In Arkansas it is not uncommon for a deer to load up on at the shot. Even on a walking deer. I have seen some very athletic deer. There is a lot of pressure on the deer in my part of the country and they probably all have ulcers. Very skittish. I have hunted in areas or other states where this wasn’t an issue at all. I think a lot depends on the pressure