First time i flew home from Texas to Oregon with 100# of meat i used a lightweight hard cooler and paid extra for over weight luggage. Frozen meat only, no ice. The only issue i had was that TSA opened the cooler and looked through all of it. As long as it was in clear wrapping and they could see it was meat, there was no problem. If i would have had it all cut and wrapped with butcher paper it would have been a nightmare. I did have some wrapped like that, and they opened it. Damn good thing i checked in real early, because that whole security bit took an hour. They also went completely through my other luggage.
The next time i went, i shipped all my gear home via Fedex, and checked in 2 boxes of frozen meat 50# each that i sealed in plastic bags AFTER i went through TSA inspection. I just told them what i had upfront to check in and wanted the inspection done BEFORE i sealed the bags. That went smoother by far. I used clear zip lock bags on everything. Kirk