I think it does matter thats why many bowyers ask,,,,, it comes down to where the string nock will be. I like to shoot really close my doe was 5yds and my buck was 13 so I shoot split and what I noticed is with a bow tillered for both It takes longer for my arrows to straighten after let off I went nuts trying to get my string nock right it wanted to be so high and thats how I know now if a bow is not tillered for split I think the bottom limb is weaker maybe making up for that extra finger. honestly I don't really know but I do know if I got a bow thats tillered for split the bare shaft tuning is easy.
I have 1 of Rons bows an original Darton Preditor and I shoot it split and my nock is at 3/8" not 5/8" high if it were tillered the other way.