I hesitate to mention it, but there are numerous rivers in the Ozark National Forest and Ouchita National forest where you can put in at one road crossing, float to another, enjoy excellent smallmouth fishing and hunting the whole way (in October), and stand a good chance of not seeing another human being. But, it's not east of Mississippi, obviously. Beautiful country though, with excellent hunting and fishing. There are the two or three "famous" rivers (Buffalo, Crooked Creek) in the area, but there are lots of lesser known rivers with equal quility fishing and many fewer people. I am not going to name specific rivers, but any state or county map will show all you need.