With a new bow, I will set it close to what the manufacturer's recommendation is, to see how it feels and sounds; to set the nock point, and watch how the arrows react, from 10 yards to 30 yrds. I may take the silencers off and shoot some. Invariably, will reset them closer to the recurve. No brush buttons with silencers. Next stage is to lower the string, so the feathers just touch the sight window and begin testing. Increase the twists by 5 then reshoot, following pretty closely to what Jacobsladder outlined. Prefer to keep it as low as possible based on grouping, feel and sound. The string should have 1.5 twist per inch at the final point, which may mean a new string. I shoot one string then keep it as a spare and breakin a second. I may try a heavier string if I not satisfied with the original. Usually try different arrows, spine and weight and almost never end up with something completely different than the norm.
The longbows are easier, nocking point and as low as possible so the feathers touch the handle. Rarely, do I end up changing it much. I'll spend time shoot shooting different spine and weight arrows. Usually, no silencers, possibly a heavier string.