Go for it!
A 45 pounder, and one that you made would be a great hunting weapon!!
Wish I had the skill to make one.
45 is plenty, get arrows that shoot well, and go hunting!
It may not feel tough to you, but at 45lbs, it will feel "tough" to what ever you shoot with it!
(For what it is worth, my "go to" bow is a 44# Black Widow longbow)It has killed everthing I have ever shot with it from squirrels, hogs, to deer. And our Florida whitetail isn't much smaller than your South Carolina deer!
Good luck my friend!
John