With traditional equipment, you will do more tuning of the arrows than the bow. There are not many adjustments to make to your bow beyond brace height, which is more to get the bow quiet than to affect arrow flight though it does have minimal affect, and nock height, which affects up/down flight mostly through avoidance of shelf contact.
Your arrows need to be spined to fit the bow you are shooting at your draw. Depending on the type of shaft, your tuning options include cutting to length and adjusting point weight to fine tune arrow flight. Wood, aluminum and carbon all behave a bit differently and react to trimming and weight in similar but more or less dramatic ways. Center shot bows are more forgiving of spine differences than those that are not.
You will need to post more specific information about your setup to get more than this general info.
Russ