It might matter.
A 2 piece is gonna be lighter in the hand and assembling it is easier.Usually requiring no tools.You wont have to tinker with bolts,washers or allen wrenches.The 2 piece is elegant,streamlined and on many you cant even tell if its a T.D.The 2 piece is very light to carry and or pack in.
If you bust a limb on a 2 piece you need a whole new bow.2 piece longbows pack well and take up very little space.Bundled together in a 2 piece bowsock its a tight little package
If you like more mass weight in your bow the 3 piece is gonna have that.Some are pretty light though.Especially with some of the smaller risers available now.You can get different poundage limbs and different lengths so its more versatile than the 2 piece in those aspects.A Morrison Shawnee with Dakota limbs for instance has A,B,C,D, and E limbs and also 3 different riser lengths.
If you damage a limb you get new limbs.
I have used both alot.I think my favorite is a 2 piece with a steel sleeve and contoured grip.Thiers alot of good 2 PC. systems available.I do like the bowbolt.My bowbolt bows had all phenolic risers.Its very strong that way and adds a little bit of wieght.Something to consider with your bow if you go the bow bolt route.