My thoughts:
Once above 8 grains per pound of draw weight your time is better spent making sure the arrows are flying perfect……….on every shot. A straight flying arrow will do more for penetration then most anything, provided you are using a cut on contact broadhead. Personally, I have taken elk with arrows ranging in weight from 475-640 grains. My most recent glass bow set up is 51# @ 29” with a 625 grain arrow. I shoot whatever weight arrow that flies best out of my selfbows, providing the weight is over 500 grains. Your bow weight will be fine in most circumstances, just be prudent with shot selection and do not press the bows/your limits.