This is different, but I shot deer with 70 pound compounds with screw in snuffers that weighed 125 grains. I think from that expierence that getting them where they cut easily is more important than horsepower. They penetrate so quickly and easily with that sharp tip, which is real sturdy on the heavier heads, that sharp blades will always slide them on thru easily.
I am ashamed to say this almost, but I wasn't and still am not the sharpest tool in the shed, but at the time I started using them I had no earthly idea how to get one sharper than a butter knife. So penetration really suffered even outta that compound compared to after learning how to get them even remotely sharp.
Now I can get them hair popping sharp using Rick Barbee's method. So my point is even with low poundage bows in the light 40's, a real sharp one will zip right thru, while even with a lot of horsepower, the dull ones don't do as well. I suspect the reason that you here this question so much is precisely this reason. Most simply do not know how to or care to get them really sharp.
It is a learned techniguue that is makes it much easier get it scary sharp even on the steep factory angles. So get your sharpening right and you will be more than fine. I once knocked a 125 grain off a shelf from36 inches high on accident and it penetrated over an 1/8 inch into real oak floors. So they will get'it done if you do your part regardless of bow weight.
BTW: The heavier ones are better so stick with the 160's plus 43 grain insert with stock insert or a 50 grain brass arrow insert, depending on what you want. I personally would be fine with either and expect to pull it out of the ground after a complete pass thru. God Bless