The biggest notice is the difference in weight, but you're also going to notice a smaller shelf on a thinner bow, a smaller grip, and all around different manners when you shoot it.
I've always said that it's not about the bow, it's about you putting the same bow in your hand over and over and learning to shoot it well.
For me, having a heavy riser in a 3 piece takedown just helps me be accurate with the same bow so much. I've shot a Kodiak Magnum for a few years before I got my takedown, and although I was proficient with it, I never felt deadly. Getting a takedown with that extra mass in the riser changed that completely for me.
It's all about personal preference. I've chose to go the route of buying from the classifieds here, if something doesn't fit me or if I don't shoot it well, just resell it and buy something else I see that I'd like to try. All trial and error.
Good luck!