Alex,
From what I've seen (if comparing a broadhead of similar lengths/widths) you may soften your spine with the 180gr tip.
It's very minimal though.
If tuned properly, a 100gr insert and a 100gr magnus will fly great. I've used a 100gr insert with a 125gr stinger with great results.
For example,
I was playing around with two setups at the start of the year, one with a 125gr tip and a 150gr insert and a 200gr tip with a 75gr insert. To get them to shoot bullet holes, the 200gr tip arrow was 1/2" longer (throat of nock to end of insert). With the field points screwed in, they were only 1/4" in difference.
In my opinion, even though the total weight up front is equal, having the weight positioned more forward will soften spine.
Again, minimal though.