I'm a little different than most, but having played with lighter weights and wood arrows I'll offer my perspective. Myself and others get our best arrow performance with a higher FOC and 500+ grains of arrow weight. Sitka Spruce makes for a lightweight, tough and very good shoooting shaft that can be teamed with a heavy broadhead to give good finished arrow weight and excellent performance on game. A 2 blade single bevel Grizzly or Griz Kodiak head would be my choice, but you would probably be fine with a narrow 3 blade like a VPA or Griz Instinct. All of these can be had in the 200 gr range,providing good FOC and total arrow weight.
For many years, 40-45 lb was the most common draw weight for deer hunters and they killed tons of deer with cedar arrows and 125 gr points. Most of those however, were shot from the ground and quite frankly, we lost quite a few, too. Most whitetails are hunted from treestaands these days and the higher shot angle requires more penetration to get an exit hole which is very important for a good blood trail. Anything that can be done to optimize arrow performance will help.