I've shot the Big Jim Big-3 and the VPA 1 1/4" 250 gr Terminator for the last several seasons... Still shooting the same several heads I started with... Bows are in 62# - 85# range with arrows in the 600 - 850 grain range... Haven't had to pull one from a critter yet... All have been stuck in the dirt on the other side...
Your setup will perform right on line with my results as long as you do your part... As Jim said, big bones stop broadheads short... Be it 2, 3, or 4 blade... Simple physics... But big broadheads can turn a less then ideal shot into a kill shot due to their size... Again, simple physics...
All that being said, I haven't found a better 3 blade head on the market then the VPA (be it Big Jim's or VPA's). Easy to sharpen, and tough as any...