Hi Pat, I have never had issues with RW/LW. I use natural turkey and goose a lot so in order to use all my feathers, I fletch both without a problem.
The one time I had a problem is when I had a bad fletching jig and the feathers were not aligning well and it caused erratic flight.
Usually the arrows aren't tuned well if there is poor flight, it's not the feathers RW/LW. Although a borderline spined arrow may have the feather/quill hit the bow and deflect a touch more I would guess.