Rolla, Missouri elevation 1,122 ft and Elevation of Lizard Head Wilderness area / unit 71 is between 10,250 and 12,000+ ft (from the internet).
Unit 71 looks like Gorgeous Country.
I live at 3200 ft and hike often to 5,6 and 7,000 ft. I have noticed the difference at 8,000 and 10,000 ft the few times i have been at that elevation.
Do what you can to get physically ready. That is alot of difference in elevation, something to think about.
It looks like beautiful country and the trip should be fun. You'll have a few more red blood cells at the end of it. Get Ready, Keep moving.