The key is the elevated rest - a flipper style like a "Weather Rest" or a spring arm style will work great. I have 1 bow specifically set up for rainy day hunts. I have too limited hunting time as it is to stay home when it's raining, so I needed to adapt once I got rid of the compound.
That bow is set up with a T-1000 rest (I think that's what it's called), and I shoot 4" 4-fletch vanes. I shoot AAE Plastifletch vanes because they are softer than most vanes on the market. However, just for kicks I shot an arrow with blazer vanes out of the set up and it shot perfectly. I don't like the look of those though - but my point is that it will work fine.
I still crested the arrows and kept the traditional look that appeals to me, but they have vanes. I also use a Selway Softkote quiver on that one and the small Simms silencers so that everything is waterproof on this particular bow.