If you can handle 45#, I'd go with that. With a sharp 2-blade head, it's plenty for deer size critters. Probably get the job done on larger critters as well, but for elk and bigger animals, I'd recommend more weight. Nothing saying you can't get a heavier bow later.
There's some renewed interest in string follow bows lately. Because they don't have as much initial weight at brace vis-a-vis a bow with setback limbs, some folks find them a bit smoother on the draw. On the other hand, they have a little less performance than a bow with straight or set back limbs., i.e., they're slower.
Reverse handle is also seeing some recent interest. A reverse handle flexes the limbs less compared to a regular straight grip for a given draw length. That, too, generally means a bit less performance. A reverse handle can help accommodate a very long draw by reducing stress on the limbs.
Not talking big differences here, but in a Hill bow, I think some backset in the limbs is the best design. Gives the best performance, and any differences in draw smoothness are negligible and probably not noticeable by most. Good luck.