I have taken this shot, it was my second shot on a buck that I already hit 18 yards out. He ran directly under my stand after I sent a arrow through the rib cage. He ran about another 30 yards and collapsed.
As for a first shot scenario, Its a high risk shot on a animal that I respect. So the answer is no, rather wait for a better shot for a several reasons, one, deer will certainly jump, move erratic at the time of the shot changing a lot of factors such as exit holes. When the deer calms down that there's a good chance that the organs, membranes, intestines may be covering the exit hole thus making it difficult to track the animal. Another reason is the higher your up, stepper angle of the shot, the smaller the vitals are to hit. It's just my opinion.