I use an Ameristep Penthouse blind. I've shot several critters from it (and a few misses), and never had a problem. I've shot 2 blade and 3 blade broadheads through it, plus a few Ace blunts. FWIW, my bow isn't cut past center, and accuracy was good enough to double lung a squirrel a week or so ago (with a blunt).
Don't worry about taking a few practice shots--the holes left are very small and won't hurt anything. I've got umpteen holes in my netting, and the critters still don't notice.
Shooting from a blind can mess with your depth perception, and it will seem to get dark a little quicker from the inside, and your visibility can be limited. Those are the only negatives I know of.
Chad