I'm no expert, but I don't think it makes a hoot of difference as long as you tune your nocking point setting for proper arrow flight. I have a morrison shawnee with 3/16" positive tiller on the top limb. Just to see what would happen, I reversed the limbs on the riser and shot the bow. I did not see any difference in arrow flight and accuracy was the same. The nocking point was set the same at 7/8" above. This was with my 56" limbs and for some reason, I seem to need a higher nocking point for shorter bows.