The pressure on the handle should be at the meaty part of the hand along the base of the thumb. It doesn't matter whether you like a high, medium, or low wrist.
In this next photo, I put too much hand into the bow on the grip. Notice how close the string is to my arm. Everything looks straight, but I'm not drawing to my left shoulder, I'm drawing to my right cheek. I'd actually be pulling the string to the right which will cause the bow to torque in my hand, sending the energy to the left, striking my arm. The bigger problem is there is no alignment as my shoulders will end up pointing off to the left and I will either have to lock my elbow or break my wrist when I draw to make up for the lack of support.
In this last photo, I've have a proper grip and have rotated my elbow out slightly. This lines up my shoulders with the bow. The pressure is all straight into the bow from the shoulders down. Notice the string is farther away from my arm. This allows me to pull straight back to anchor without torquing the bow. The energy will be straight forward on release.
Hope this isn't too confusing and helps you out.