Howard hill said you can take any animal in North America (American bison, moose, muck ok, etc) with a #40 bow. He was talking a Howard hill style bow. If you add in modern advances like r/d limbs, efoc arrows, single bevel, skinny string, etc you might have a good chance with #43. I suggest you buy the most efficent bow at #43 you can (belcher ssr 205fps fingers 10gpp 28in draw), follow Ashby's instructions on arrow weight, efoc, tapered shafts, etc and get the slickest strike plate, shelf, lighest silencers, etc. Maybe even use the heaviest spine weight grizzly stiks with the Ashby head. I would test the setup here first on game and possibly a cow carcass if you can. Then you decide if it is sufficient.