I knew this would generate some controversy and discusson! The risk of malaria in southern Africa certainly varies greatly by location and season, and RSA in (their) winter is indeed a low risk area. But it only takes one mosquitoe! Partial immunity from prior exposure significantly modifies the course of the disease, which is one reason so many locals are fairly casual about it. But we don't have any immunity, which puts us at much greater risk of serious complications if we do get it. Yes, I absolutely take doxycycline prophalactically every time I go, starting a week before departure and continuing for six weeks after I get back. (In light of some more recent studies, I take it even longer after returning from a really high risk area like Zambia.) While I don't think any scientific studies have been done, the agent responsible for what's called tick fever in Africa (and Boutenouse fever in medical texts) is generally sensitive to tetracyline antibiotics so doxy may well offer some protection. No med can prevent malaria totally. Remember that the Anopheles mosquito only flies at night. Wear long sleeves and insect repellant after sundown. Part of my strong feelings on the subject stem from several experiences in my medical career when I cared for young,previously healthy people who traveled to Africa, didn't do any of these things, came home, developed malaria and died despite all the resources of the best modern medical care available anywhere. That left quite an impresssion. Oh... remember that you wouldn't ask your doctor about shot placement on a kudu. You shouldn't ask your PH for medical advice for the same reason! Cheers all, Don