I often splice boards with either W, V, or Z splice. If I am splicing a 1/2" thick board or so, then adding a handle and a backing, they never come apart on me. I have not induced setback this way but have done a jillion other things. Once I spliced the boards, then thinned the area with the splice, and introduced deflex there while glueing up an Oreo handle.
Also, I make a lot of tri-lams and just use a skive splice and stagger them at each layer.
Lastly, I just bought a router bit tha does finger-joints. I am positive that finger-jointing lams will be really strong, as long as I am using a backing and handle piece..