The riser should be centered at glue up, at least that's where I've seen it done more often than not. The arrow shelf is cut in such a way that the arrow passes over it about 1.5" I build glass bows so others who dont use shelves and shoot off their hand know differently. I also dont know anything about bows that bend through the handle.
But for glass bows, and I suppose any bow with a riser attached to it, the note above is valid. Hopefully someone else will agree with me here.