I do it all the time. It works great with Smooth On. Our oven is pretty accurate down to 125F, so I cook a clamped-up riser at about 175F for 5 hours. I've never noticed any bad smell and, as long as the riser is well wrapped in Saran Wrap or its equivalent, no problem about epoxy dripping. I usually clamp up and bake some laminates for bow tips at the same time -- kind of like an appetizer for the main course.
My wife is hounding me, however, about epoxy on her oven door handle. I probably ought to change gloves before I open the oven. Anyone know a good epoxy solvent that won't hurt stainless?