I trace the grain from end to end with a pencil for starters. That will be your left-right reference when laying out the bow's width profile. If the pencil line runs off the stave to the side or goes through a bad spot, trace a new line for a better layout and erase the old one.
Next, review the stave to see where the best section for a bow lies. Mark where the string grooves will be, and where the true center of the bow will be. If you want asym limbs, choose whichever one is cleanest and straightest for the bottom limb. Make another mark one-half the difference in limb length just below the mark for the mid-point. (For example, if you want a bow with an upper limb 1.5" longer than the lower, make a mark 3/4" below the mark for the stave's mid-point.) That mark sets the center of your grip, and is the reference you'll use from here on out. Erase mark for the true mid-point. It's no longer needed.
From the center of grip mark, now mark (equally) the ends of the grip and the fades. The grip will be 4" long (approx width of hand). The mark for the top of the grip is also the location of the arrow pass (2" above the grip center). Finally, lay out the bow's entire width profile that you want, relative left-right to your traced grain line, and relative lengthwise to the cross-marks you've made for the grip, fades, and string grooves.
When you start tillering an asym bow on a rope & pulley tillering tree with the grip set more or less firmly in a cradle and the rope clipped on the string from where it will be drawn, you'll see the rope pulls down and towards the bottom limb (if the tiller is right), essentially replicating how the bow is actually drawn by hand.
Another option is to either balance the center of the grip on a small block of wood or place the grip in a leather sling. The bow will rock on the block or wood or in the sling when drawn and the rope will pull straight back. Either way will simulate how the bow will really be drawn.