I see what you are getting at with your question.
I approach it a little differently. I start by deciding what type of bow I want. My goal is not to make a bow that will survive, but to make a bow that will perform in its intended role.
Let's say I need to make a bow for someone with a 29.5" draw, and the guy wants to hunt from a blind, so the bow can't exceed 62", and needs to be minimum 45#, and assume the guy wants a stiff handle bow. I know that a straight limb bow of that length will stack badly, so I know I need to have deflex in order to improve string angle, and I will need some reflex to keep performance up to a reasonable level.
D/R bows have that benefit, they let you make a shorter bow for a given draw length without sacrificing string angle.
So in my example, I now know I will make a 62" D/R bow, it may be a recurve or may be a longbow depending on if I also flip the tips a lot. Then I will decide on materials and dimensions to achieve that.
In this case I might use ipe or osage belly, hickory or bamboo backing, and whatever core material I've got available. The critical decision really is 'how wide do I need to make it'.
No one can tell you exactly, but I would probably go 1.5" wide. Then it's just down to tillering.
But to answer your question directly, if you had two, well let's make it three bows of the same length and width and materials, one with straight limbs and flipped tips, one with even reflex along the limbs, and one with deflex and reflex, all three have the tips in the same position relative to the throat of the grip. In this case, there should be almost no difference in strain on the wood (aside from the benefits of perry reflexing).
The D/R bow should perform the best at a given draw weight.
Both the DR and the reflex bow will benefit to some degree from the perry reflexing, and the bow with flipped tips I would expect to take the most set.
You're question is which is easier .... They are all the same difficulty. If you tiller well, all will work fine, if you tiller poorly, all will break.
Sorry for the essay.