Im right hand and left eye,,,; not a problem has never been a issue... i shoot instinctive though so i just look... if anyone is aiming with both eyes open even if you are unknowingly aiming then yes big problem.....: curious if you are subconciously aiming? then go outside in the pitch dark and have someone stand 20' to the side of you and aiming a tight beamed flashlight at the target and see how accurate you are,,,, if you are true instinctive you will shoot just as good as when its sunny out... as for guns i shot on a trap team for 7 yrs and never had a prob,,, i do close my left eye and prefer a flat rib and no beads on my shotguns when shooting trap or bird hunting.