I have lost 1 and my buddy lost 2 before we decided to find out why, what we thought were "perfectly" hit birds, were running off, never to be seen again. We did field autopsy's to examine the vitals and determine where the vitals actually were and where they should be shot, not where most of the "experts" and targets were telling you to shoot them. Several birds later, I can attest that our experimenting has been a success and I always try to share this knowledge to all those getting into it so they do not experience the frustration and sorrow of loosing an animal.
All targets and most people will advise a shot to the wing butt as most effective, granted, I can add that if you hit that 1/2in spot perfectly, it is devestating, but shoot a little high, low or forward and there is nothing vital there and you will loose that bird. The vitals on a turkey are much lower and back then most people realize and their heart actually sits just above the hips on a broadside turkey. I always try to shoot just a little above and just forward of the hips on my birds and I always place my jake decoy around 10-15yds away so I know I will have a close shot. If you hit a little higher or lower you will still get the bird and take out his hips or legs and he will not be able to fly away, at least until you can catch him. If you thump a bird right in the spot, let him go and lay down, even if he does not die immediately, he will be close and by not chasing him, you will allow him to remain in the area and not run or fly where you cannot track them. Occasionally you will hit one that will just drop and lay there, only to jump up and run off, but normally you can still get after the bird and find him, but that is better then jumping up after him and watching them fly off 200 yds. away or more. On straight away shots aim just below the butt and facing shots, just below the beard.
I always recommend using a very large, multi blade head to do the most damage to the bird and do not use any stoppers or adders, your arrow will almost always stay in the bird and you do not need to reduce penetration anymore. I almost lost my 1st bird I shot due to the adder catching the primary wing feathers and not letting the broadhead get into the chest.
I am sharing this information so you can learn from others mistakes and improve your chances on bagging that bird. Mark