I wear merino wool hiking socks, and a silk liner sock under those.
Footwear must fit well, and be well broke in. I wear Vasque hiking boots W/full steel shank for high country hunting. The flexible shank boots just kill me when walking in steep terrain, though others have no problems with them.
Carry 4-5 pairs of socks and liners. Change them often, and wash the used pairs at night if possible.
Moleskin can be a trip saver. Better to have some and not need it, then to need some and not have it.
Treat your boots well with whatever product the manufacturer recommends for a water proofing. Wet feet ain't going to be happy feet.
Lace the boots up as Noelkman recommends. THEN, after you have hiked for an hour or so, relace them to your liking, as your feet will swell a bit, and your boots may get tighter than you are comfortable with.
Don't try to dry your boots by a campfire unless you are WATCHING them! Burning your boots is not a good thing to do!
And don't ask how I knows this!