I hunt whitetail, turkey and small game with a 45# recurve. I used 125 grain b'heads on 2117 shafts, in the past, but also mess around with woodies as well.
IMHO the biggest factors to successful hunting are:
Be still. You'd be surprised at how close an animal will get to you if you are patient. Getting busted because the wind changed direction happens, but that's part of the fun.
Accuracy. You need to be able to hit the spot. With my set up, I am confident that out to 20 yards, I will hit what I'm pointing at. I practise longer shots (up to 100 yards) for fun. But every shot I've taken in a hunting situation has been 20 yards or less.