I shoot the 160's more than anything else. BIG HOLES! As for penetration, Dan Quillian used the 160 on my Superceder shafts to kill the record-class grizzly that we used in our advertising. Dan got complete penetration to the hide on the opposite side, quartering away at 15 yards. I've never worried about penetration since seeing that! The hair, hide, and fat alone were several inches thick. His bow was a Bamboo Longhunter longbow that pulled around 70#, and the finished arrows weighed around 650 grains.
I've shot only deer with mine, and haven't had a loss with them, even on a couple of bad hits. BIG HOLES!