"When in doubt - back out!" This little reminder is very useful. Its always better to come back hours later or even the next day and find your deer close than to bump them and have them run a mile.
After the shot, watch and mark that last place you could see the deer and take a compass reading of the direction it was traveling.
Use toilet paper to mark the trail. Its biodegradable and you should have it in your pack.
If you have a certain broadside double lung with bubbles in bright red blood on the arrow, your deer will not go 150 yards. Dark blood is from veins or the liver, back out.
Bring help. One person stands at the last blood while the other looks for the next. If you have two helpers, one can loop ahead and look for the animal. Walk next to the blood trail, don't trample the sign in case you have to restart.
If the blood trail ends. Sit down and think. Look around. Where would you go if you were a wounded deer? Sometimes the end of the blood trail means a muscle hit that clotted and the deer survived. Sometimes it means the deer ran out of blood on the run and it is very close.
Sometimes deer stop and spring sideways several yards when they expire. Look around up to 10 yards on each side of the last sign.
If you think you heard the deer "crash", you did. He is right there every time. Go get help anyway so you can share the moment.