Yep.....switched from right to leftie 20 years ago. I still shoot right handed, but prefer to shoot leftie, and do 90% of the time. It's not as difficult as it may seem.
The first couple of days will feel strange, but you pick up on it pretty quick.
Shooting a bow is the one and only thing I do left handed.....looking back, when I shot a lot, the arm I held the bow with got tired (left). I'm naturally right handed so my right arm is stronger than my left....switching to holding the bow with my right hand was a big help in not getting tired as quickly.