Always shot simple two blade, no reason to change. Whitetails, elk, hogs, black bears, bison, red stag, coyotes, turkey, small game....not a problem yet. I like to think the less chance of snagging up on something the better, so I keep it to just a thin two blade. Never had a problem with bloodtrailing either. A good shot leaves a heavy trail, even in long haired game.
Zwickey, magnus and STOS, for me, but I'm sure any of the quality brands will do fine.
SCHunter has it on the head though, you should really shoot what makes you feel the most confident.